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levamlodipine besylate (HuiDa RC International Inc)

Name: levamlodipine besylate
Brand: HuiDa RC International Inc
Rating: 90 (1 reviews)

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HuiDa RC International Inc levamlodipine besylate

<t>Levamlodipine</t> <t>Besylate</t> restores spatial learning and memory in VaD mice. Eight weeks after rUCCAO operation, Levamlodipine Besylate was administered orally ( p.o .) at 0.1 or 0.5 mg/kg, and Mementine was administered orally ( p.o .) at a dose of 20 mg/kg for eight weeks. The Morris water maze experiment was used to test the spatial learning of these mice. ( a ) The changes in escape latency were probed to find the hidden platform produced during training trials in each group. * f (10,10) = 5.97, # f (10,10) = 3.44, * p < 0.05 verse sham group; # p < 0.05 verse vehicle group. (means ± SEM, n = 10 mice in each group) ( b ). On the fifth day, each mouse was tested in a probe trial by removing the platform from the pool. The platform crossing time were recorded. * f (10,10) = 4.43, * p < 0.05 verse sham grou p . (means ± SEM, n = 10 mice in each group) ( c ). Time spent in target quadrant in the test day (means ± SEM, n = 10 mice in each group) ( d ). Path length of mice during the MWM test. (means ± SEM, n = 10 mice in each group).

Levamlodipine Besylate, supplied by HuiDa RC International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia"

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

Journal: Scientific Reports

doi: 10.1038/s41598-019-47868-0

Levamlodipine Besylate restores spatial learning and memory in VaD mice. Eight weeks after rUCCAO operation, Levamlodipine Besylate was administered orally ( p.o .) at 0.1 or 0.5 mg/kg, and Mementine was administered orally ( p.o .) at a dose of 20 mg/kg for eight weeks. The Morris water maze experiment was used to test the spatial learning of these mice. ( a ) The changes in escape latency were probed to find the hidden platform produced during training trials in each group. * f (10,10) = 5.97, # f (10,10) = 3.44, * p < 0.05 verse sham group; # p < 0.05 verse vehicle group. (means ± SEM, n = 10 mice in each group) ( b ). On the fifth day, each mouse was tested in a probe trial by removing the platform from the pool. The platform crossing time were recorded. * f (10,10) = 4.43, * p < 0.05 verse sham grou p . (means ± SEM, n = 10 mice in each group) ( c ). Time spent in target quadrant in the test day (means ± SEM, n = 10 mice in each group) ( d ). Path length of mice during the MWM test. (means ± SEM, n = 10 mice in each group).

Figure Legend Snippet: Levamlodipine Besylate restores spatial learning and memory in VaD mice. Eight weeks after rUCCAO operation, Levamlodipine Besylate was administered orally ( p.o .) at 0.1 or 0.5 mg/kg, and Mementine was administered orally ( p.o .) at a dose of 20 mg/kg for eight weeks. The Morris water maze experiment was used to test the spatial learning of these mice. ( a ) The changes in escape latency were probed to find the hidden platform produced during training trials in each group. * f (10,10) = 5.97, # f (10,10) = 3.44, * p < 0.05 verse sham group; # p < 0.05 verse vehicle group. (means ± SEM, n = 10 mice in each group) ( b ). On the fifth day, each mouse was tested in a probe trial by removing the platform from the pool. The platform crossing time were recorded. * f (10,10) = 4.43, * p < 0.05 verse sham grou p . (means ± SEM, n = 10 mice in each group) ( c ). Time spent in target quadrant in the test day (means ± SEM, n = 10 mice in each group) ( d ). Path length of mice during the MWM test. (means ± SEM, n = 10 mice in each group).

Techniques Used: Produced

Levamlodipine Besylate can improve the recognition memory impaired in VaD mice. The novel object recognition test (NORT) was used to evaluate recognition memory. The time spent exploring novel object ( a ) and frequency exploring novel object ( b ) were recorded and analyze. * p < 0.05 verse sham group; # p < 0.05 verse vehicle group; ## p < 0.01 verse vehicle group. (means ± SEM, n = 12 mice in each group).

Figure Legend Snippet: Levamlodipine Besylate can improve the recognition memory impaired in VaD mice. The novel object recognition test (NORT) was used to evaluate recognition memory. The time spent exploring novel object ( a ) and frequency exploring novel object ( b ) were recorded and analyze. * p < 0.05 verse sham group; # p < 0.05 verse vehicle group; ## p < 0.01 verse vehicle group. (means ± SEM, n = 12 mice in each group).

Techniques Used:

Levamlodipine Besylate prevents the dephosphorylation of CaMKII in rUCCAO mice. A significant decrease in the intensity of fluorescence for phospho-CaMKII (Thr286) in CA1 pyramidal neurons of the hippocampus. Levamlodipine Besylate (0.1 mg/kg) could restore the decrease in immunostaining for phospho-CaMKII (Thr286). ( a ) Representative images of phospho-CaMKII in hippocampus CA1 region. ( b ) Quantification of phospho-CaMKII in CA1 region.

Figure Legend Snippet: Levamlodipine Besylate prevents the dephosphorylation of CaMKII in rUCCAO mice. A significant decrease in the intensity of fluorescence for phospho-CaMKII (Thr286) in CA1 pyramidal neurons of the hippocampus. Levamlodipine Besylate (0.1 mg/kg) could restore the decrease in immunostaining for phospho-CaMKII (Thr286). ( a ) Representative images of phospho-CaMKII in hippocampus CA1 region. ( b ) Quantification of phospho-CaMKII in CA1 region.

Techniques Used: De-Phosphorylation Assay, Fluorescence, Immunostaining

Effect of Levamlodipine Besylate on brain vascular structure in rUCCAO mice. ( a ) Representative immunochemistry image of brain blood vessels in hippocampus CA1 region. No significant effect on the vascular structure were observed following Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment. ( b ) Blood pressure of different group of mice.

Figure Legend Snippet: Effect of Levamlodipine Besylate on brain vascular structure in rUCCAO mice. ( a ) Representative immunochemistry image of brain blood vessels in hippocampus CA1 region. No significant effect on the vascular structure were observed following Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment. ( b ) Blood pressure of different group of mice.

Techniques Used:

Effect of Levamlodipine Besylate on the activation of astrocyte in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment has no significant effect on the activation of astrocyte.

Figure Legend Snippet: Effect of Levamlodipine Besylate on the activation of astrocyte in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment has no significant effect on the activation of astrocyte.

Techniques Used: Activation Assay

Effect of Levamlodipine Besylate on microglia activation in rUCCAO mice. Iba-1 expressed in the hippocampus neurons of vehicle group was significantly increased in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment did not significantly attenuated rUCCAO-induced microglia activation in the hippocampus.

Figure Legend Snippet: Effect of Levamlodipine Besylate on microglia activation in rUCCAO mice. Iba-1 expressed in the hippocampus neurons of vehicle group was significantly increased in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment did not significantly attenuated rUCCAO-induced microglia activation in the hippocampus.

Techniques Used: Activation Assay

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Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Levamlodipine Besylate restores spatial learning and memory in VaD mice. Eight weeks after rUCCAO operation, Levamlodipine Besylate was administered orally ( p.o .) at 0.1 or 0.5 mg/kg, and Mementine was administered orally ( p.o .) at a dose of 20 mg/kg for eight weeks. The Morris water maze experiment was used to test the spatial learning of these mice. ( a ) The changes in escape latency were probed to find the hidden platform produced during training trials in each group. * f (10,10) = 5.97, # f (10,10) = 3.44, * p < 0.05 verse sham group; # p < 0.05 verse vehicle group. (means ± SEM, n = 10 mice in each group) ( b ). On the fifth day, each mouse was tested in a probe trial by removing the platform from the pool. The platform crossing time were recorded. * f (10,10) = 4.43, * p < 0.05 verse sham grou p . (means ± SEM, n = 10 mice in each group) ( c ). Time spent in target quadrant in the test day (means ± SEM, n = 10 mice in each group) ( d ). Path length of mice during the MWM test. (means ± SEM, n = 10 mice in each group).

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques: Produced

Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Levamlodipine Besylate can improve the recognition memory impaired in VaD mice. The novel object recognition test (NORT) was used to evaluate recognition memory. The time spent exploring novel object ( a ) and frequency exploring novel object ( b ) were recorded and analyze. * p < 0.05 verse sham group; # p < 0.05 verse vehicle group; ## p < 0.01 verse vehicle group. (means ± SEM, n = 12 mice in each group).

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques:

Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Levamlodipine Besylate prevents the dephosphorylation of CaMKII in rUCCAO mice. A significant decrease in the intensity of fluorescence for phospho-CaMKII (Thr286) in CA1 pyramidal neurons of the hippocampus. Levamlodipine Besylate (0.1 mg/kg) could restore the decrease in immunostaining for phospho-CaMKII (Thr286). ( a ) Representative images of phospho-CaMKII in hippocampus CA1 region. ( b ) Quantification of phospho-CaMKII in CA1 region.

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques: De-Phosphorylation Assay, Fluorescence, Immunostaining

Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Effect of Levamlodipine Besylate on brain vascular structure in rUCCAO mice. ( a ) Representative immunochemistry image of brain blood vessels in hippocampus CA1 region. No significant effect on the vascular structure were observed following Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment. ( b ) Blood pressure of different group of mice.

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques:

Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Effect of Levamlodipine Besylate on the activation of astrocyte in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment has no significant effect on the activation of astrocyte.

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques: Activation Assay

Journal: Scientific Reports

Article Title: Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

doi: 10.1038/s41598-019-47868-0

Figure Lengend Snippet: Effect of Levamlodipine Besylate on microglia activation in rUCCAO mice. Iba-1 expressed in the hippocampus neurons of vehicle group was significantly increased in rUCCAO mice. Levamlodipine Besylate (0.1 mg/kg and 0.5 mg/kg) or mementine (20 mg/kg) treatment did not significantly attenuated rUCCAO-induced microglia activation in the hippocampus.

Article Snippet: Levamlodipine Besylate was supplied by Shi huida Pharmaceutical Group (Shanghai).

Techniques: Activation Assay

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